2bi0: Difference between revisions

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==Overview==

The Mycobacterium tuberculosis genome contains about 4000 genes, of which, approximately a third code for proteins of unknown function or are, classified as conserved hypothetical proteins. We have determined the, three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo., The structure exhibits the greatest similarity to bacterial and eukaryotic, hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A., However, only part of the catalytic machinery is conserved in Rv0216 and, it showed no activity for the substrate crotonyl-CoA. The structure of, Rv0216 allows us to assign new functional annotations to a family of seven, other M. tuberculosis proteins, a number if which are essential for, bacterial survival during infection and growth.

The Mycobacterium tuberculosis genome contains about 4000 genes, of which approximately a third code for proteins of unknown function or are classified as conserved hypothetical proteins. We have determined the three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo. The structure exhibits the greatest similarity to bacterial and eukaryotic hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A. However, only part of the catalytic machinery is conserved in Rv0216 and it showed no activity for the substrate crotonyl-CoA. The structure of Rv0216 allows us to assign new functional annotations to a family of seven other M. tuberculosis proteins, a number if which are essential for bacterial survival during infection and growth.

==About this Structure==

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[[Category: Castell, A.]]

[[Category: Johansson, P.]]

[[Category: Jones, T.A.]]

[[Category: Jones, T A.]]

[[Category: SPINE, Structural.Proteomics.in.Europe.]]

[[Category: SPINE, Structural Proteomics in Europe.]]

[[Category: Unge, T.]]

[[Category: CL]]

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[[Category: structural proteomics in europe]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The Mycobacterium tuberculosis genome contains about 4000 genes, of which, approximately a third code for proteins of unknown function or are, classified as conserved hypothetical proteins. We have determined the, three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo., The structure exhibits the greatest similarity to bacterial and eukaryotic, hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A., However, only part of the catalytic machinery is conserved in Rv0216 and, it showed no activity for the substrate crotonyl-CoA. The structure of, Rv0216 allows us to assign new functional annotations to a family of seven, other M. tuberculosis proteins, a number if which are essential for, bacterial survival during infection and growth.
+The Mycobacterium tuberculosis genome contains about 4000 genes, of which approximately a third code for proteins of unknown function or are classified as conserved hypothetical proteins. We have determined the three-dimensional structure of one of these, the rv0216 gene product, which has been shown to be essential for M. tuberculosis growth in vivo. The structure exhibits the greatest similarity to bacterial and eukaryotic hydratases that catalyse the R-specific hydration of 2-enoyl coenzyme A. However, only part of the catalytic machinery is conserved in Rv0216 and it showed no activity for the substrate crotonyl-CoA. The structure of Rv0216 allows us to assign new functional annotations to a family of seven other M. tuberculosis proteins, a number if which are essential for bacterial survival during infection and growth.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Castell, A.]]
 [[Category: Johansson, P.]]
-[[Category: Jones, T.A.]]
+[[Category: Jones, T A.]]
-[[Category: SPINE, Structural.Proteomics.in.Europe.]]
+[[Category: SPINE, Structural Proteomics in Europe.]]
 [[Category: Unge, T.]]
 [[Category: CL]]
@@ Line 28: / Line 28: @@
 [[Category: structural proteomics in europe]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:24:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:00 2008''