2bj6: Difference between revisions

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==Overview==

The crystal structure of a decameric HNA/RNA (HNA =, 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the, RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid, duplex between a naturally occurring nucleic acid and a strand, which is, fully modified to contain a six-membered ring instead of ribose. The, presence of four duplex helices in the asymmetric unit allows for a, detailed discussion of hydration, which revealed a tighter spinelike, backbone hydration for the HNA- than for the RNA-strands. The reinforced, backbone hydration is suggested to contribute significantly to the, exceptional stability of HNA-containing duplexes and might be one of the, causes for the evolutionary preference for ribose-derived nucleic acids.

The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.

==About this Structure==

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[[Category: rna]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of a decameric HNA/RNA (HNA =, 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the, RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid, duplex between a naturally occurring nucleic acid and a strand, which is, fully modified to contain a six-membered ring instead of ribose. The, presence of four duplex helices in the asymmetric unit allows for a, detailed discussion of hydration, which revealed a tighter spinelike, backbone hydration for the HNA- than for the RNA-strands. The reinforced, backbone hydration is suggested to contribute significantly to the, exceptional stability of HNA-containing duplexes and might be one of the, causes for the evolutionary preference for ribose-derived nucleic acids.
+The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
 ==About this Structure==
@@ Line 28: / Line 28: @@
 [[Category: rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:24:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:26 2008''