HIV-1 Reverse Transcriptase in Complex with Nevirapine: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
RT performs three catalytic steps: 1) RNA-dependent DNA polymerization to create a negative sense DNA strand that complements the positive sense viral RNA genome, 2) ribonuclease H cleavage of RNA in the RNA:DNA heteroduplex, and 3) DNA-dependent DNA polymerization to make a dsDNA using the previously synthesized negative sense DNA strand as a template. The dsDNA is transported to the nucleus where it integrates into the host cell's chromosome. HIV-1 is chronic and requires lifelong treatment with a combination of at least three different antiviral drugs. In addition, the emergence of drug-resistant HIV-1 strains means drugs with new viral targets are constantly being developed. | RT performs three catalytic steps: 1) RNA-dependent DNA polymerization to create a negative sense DNA strand that complements the positive sense viral RNA genome, 2) ribonuclease H cleavage of RNA in the RNA:DNA heteroduplex, and 3) DNA-dependent DNA polymerization to make a dsDNA using the previously synthesized negative sense DNA strand as a template. The dsDNA is transported to the nucleus where it integrates into the host cell's chromosome. HIV-1 is chronic and requires lifelong treatment with a combination of at least three different antiviral drugs. In addition, the emergence of drug-resistant HIV-1 strains means drugs with new viral targets are constantly being developed. | ||
<StructureSection load='3v81' size='350' side='right' caption='Crystal Structure of HIV-1 Reverse Transcriptase with DNA and the nonnucleoside inhibitor nevirapine (PDB entry [[ | <StructureSection load='3v81' size='350' side='right' caption='Crystal Structure of HIV-1 Reverse Transcriptase with DNA and the nonnucleoside inhibitor nevirapine (PDB entry [[3v81]])' scene=3v81/Overall_structure/1''> | ||
== Structure of RT domains == | == Structure of RT domains == | ||
