SecA: Difference between revisions

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=Introduction=

The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/>

The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PDB motions]].

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Revision as of 09:31, 15 November 2012 view source Michal Harel (talk \| contribs) 32,820 edits No edit summary ← Older edit		Revision as of 12:47, 18 March 2013 view source Michal Harel (talk \| contribs) 32,820 edits No edit summary Newer edit →
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	=Introduction=		=Introduction=
	The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/>		The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PDB motions]].