VlsE: Difference between revisions
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New page: thumb|300px|alt=text|VlsE ==Introduction== [http://en.wikipedia.org/wiki/Borrelia_burgdorferi ''Borrelia burgdorferi'']' is a bacterium that is classified under a... |
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==Structural Overview== | ==Structural Overview== | ||
<Structure load='1l8w' size='390' frame='true' align='left' caption='VlsE lipoprotein | <Structure load='1l8w' size='390' frame='true' align='left' caption='VlsE lipoprotein [[1l8w]]' scene='Insert optional scene name here' /> | ||
VlsE is a tetramer that consists of four identical subunits: <scene name='G21SecL01Tpc5/Chain_a/1'>chains A</scene>, B, C, and D. Making up the protein are two invariable regions, found at the N and C terminal regions, and one central variable domain <ref>PMID: 11923306</ref><ref>PMID: 10569796</ref>. Within the variable domain are six variable (VR) and six invariable regions (IR). Since the N and C terminal regions do not go through constant changes, it was thought they would make great targets for antibodies to attach to. But due to the tightly packed structure of the VlsE and its lateral surface areas binding to other proteins, the terminal regions did not react well with the antibodies. This resulted in low levels of antibody attachment to the surface of the VlsE. Instead, a region within the VlsE that is protected by the antigenic variable system, known as IR6, was found to be the most reactive towards antibodies. | VlsE is a tetramer that consists of four identical subunits: <scene name='G21SecL01Tpc5/Chain_a/1'>chains A</scene>, B, C, and D. Making up the protein are two invariable regions, found at the N and C terminal regions, and one central variable domain <ref>PMID: 11923306</ref><ref>PMID: 10569796</ref>. Within the variable domain are six variable (VR) and six invariable regions (IR). Since the N and C terminal regions do not go through constant changes, it was thought they would make great targets for antibodies to attach to. But due to the tightly packed structure of the VlsE and its lateral surface areas binding to other proteins, the terminal regions did not react well with the antibodies. This resulted in low levels of antibody attachment to the surface of the VlsE. Instead, a region within the VlsE that is protected by the antigenic variable system, known as IR6, was found to be the most reactive towards antibodies. | ||
