2bz5: Difference between revisions

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==Overview==

Docking-based virtual screening identified 1-(2-phenol)-2-naphthol, compounds as a new class of Hsp90 inhibitors of low to sub-micromolar, potency. Here we report the binding affinities and cellular activities of, several members of this class. A high resolution crystal structure of the, most potent compound reveals its binding mode in the ATP binding site of, Hsp90, providing a rationale for the observed activity of the series and, suggesting strategies for developing compounds with improved properties.

Docking-based virtual screening identified 1-(2-phenol)-2-naphthol compounds as a new class of Hsp90 inhibitors of low to sub-micromolar potency. Here we report the binding affinities and cellular activities of several members of this class. A high resolution crystal structure of the most potent compound reveals its binding mode in the ATP binding site of Hsp90, providing a rationale for the observed activity of the series and suggesting strategies for developing compounds with improved properties.

==About this Structure==

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[[Category: Brough, P.]]

[[Category: Drysdale, M.]]

[[Category: Hubbard, R.E.]]

[[Category: Hubbard, R E.]]

[[Category: Massey, A.]]

[[Category: Surgenor, A.]]

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[[Category: phosphorylation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Feb ~~3 10~~:29:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:12 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Docking-based virtual screening identified 1-(2-phenol)-2-naphthol, compounds as a new class of Hsp90 inhibitors of low to sub-micromolar, potency. Here we report the binding affinities and cellular activities of, several members of this class. A high resolution crystal structure of the, most potent compound reveals its binding mode in the ATP binding site of, Hsp90, providing a rationale for the observed activity of the series and, suggesting strategies for developing compounds with improved properties.
+Docking-based virtual screening identified 1-(2-phenol)-2-naphthol compounds as a new class of Hsp90 inhibitors of low to sub-micromolar potency. Here we report the binding affinities and cellular activities of several members of this class. A high resolution crystal structure of the most potent compound reveals its binding mode in the ATP binding site of Hsp90, providing a rationale for the observed activity of the series and suggesting strategies for developing compounds with improved properties.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Brough, P.]]
 [[Category: Drysdale, M.]]
-[[Category: Hubbard, R.E.]]
+[[Category: Hubbard, R E.]]
 [[Category: Massey, A.]]
 [[Category: Surgenor, A.]]
@@ Line 27: / Line 27: @@
 [[Category: phosphorylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:29:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:12 2008''