2bzs: Difference between revisions

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==Overview==

CB1954 is an attractive prodrug for directed-enzyme prodrug therapy (DEPT), and a conventional prodrug against tumors in which the enzyme NQO2 is, highly expressed. We have determined the crystal structure of the, NQO2-CB1954 complex to 2.0 A resolution. The binding of the prodrug is, governed by hydrophobic forces, while two key electrostatic contacts, determine the specific orientation of the ligand. The structure also, reveals an unfavorable interaction, therefore suggesting possible avenues, for DEPT-tailored engineering studies.

CB1954 is an attractive prodrug for directed-enzyme prodrug therapy (DEPT) and a conventional prodrug against tumors in which the enzyme NQO2 is highly expressed. We have determined the crystal structure of the NQO2-CB1954 complex to 2.0 A resolution. The binding of the prodrug is governed by hydrophobic forces, while two key electrostatic contacts determine the specific orientation of the ligand. The structure also reveals an unfavorable interaction, therefore suggesting possible avenues for DEPT-tailored engineering studies.

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Doughty, S.W.]]

[[Category: Doughty, S W.]]

[[Category: Heap, J.T.]]

[[Category: Heap, J T.]]

[[Category: Kellam, B.]]

[[Category: Khader, M.M.Abu.]]

[[Category: Khader, M M.Abu.]]

[[Category: Matteis, C.De.]]

[[Category: Matteis, C De.]]

[[Category: Minton, N.]]

[[Category: Paoli, M.]]

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[[Category: zinc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Feb ~~3 10~~:29:47 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:21 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-CB1954 is an attractive prodrug for directed-enzyme prodrug therapy (DEPT), and a conventional prodrug against tumors in which the enzyme NQO2 is, highly expressed. We have determined the crystal structure of the, NQO2-CB1954 complex to 2.0 A resolution. The binding of the prodrug is, governed by hydrophobic forces, while two key electrostatic contacts, determine the specific orientation of the ligand. The structure also, reveals an unfavorable interaction, therefore suggesting possible avenues, for DEPT-tailored engineering studies.
+CB1954 is an attractive prodrug for directed-enzyme prodrug therapy (DEPT) and a conventional prodrug against tumors in which the enzyme NQO2 is highly expressed. We have determined the crystal structure of the NQO2-CB1954 complex to 2.0 A resolution. The binding of the prodrug is governed by hydrophobic forces, while two key electrostatic contacts determine the specific orientation of the ligand. The structure also reveals an unfavorable interaction, therefore suggesting possible avenues for DEPT-tailored engineering studies.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Doughty, S.W.]]
+[[Category: Doughty, S W.]]
-[[Category: Heap, J.T.]]
+[[Category: Heap, J T.]]
 [[Category: Kellam, B.]]
-[[Category: Khader, M.M.Abu.]]
+[[Category: Khader, M M.Abu.]]
-[[Category: Matteis, C.De.]]
+[[Category: Matteis, C De.]]
 [[Category: Minton, N.]]
 [[Category: Paoli, M.]]
@@ Line 32: / Line 32: @@
 [[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:29:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:21 2008''