9pai: Difference between revisions
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==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. | [[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[http://omim.org/entry/613329 613329]]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. | ||
==Function== | ==Function== | ||
