3i00: Difference between revisions

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~~[[Image:3i00.png|left|200px]]~~

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===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===

==Disease==

[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_20179344}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref><ref>PMID:11007801</ref><ref>PMID:11532990</ref><ref>PMID:11577110</ref><ref>PMID:11889126</ref><ref>PMID:12163454</ref><ref>PMID:14732715</ref><ref>PMID:16027218</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 20179344 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_20179344}}~~

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Brodsky, F M.]]

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@@ Line 1: / Line 1: @@
-[[Image:3i00.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3i00", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3i00|  PDB=3i00  |  SCENE=  }}
 ===Crystal Structure of the huntingtin interacting protein 1 coiled coil domain===
+{{ABSTRACT_PUBMED_20179344}}
+==Disease==
+[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_20179344}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/HIP1_HUMAN HIP1_HUMAN]] Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.<ref>PMID:9147654</ref><ref>PMID:11007801</ref><ref>PMID:11532990</ref><ref>PMID:11577110</ref><ref>PMID:11889126</ref><ref>PMID:12163454</ref><ref>PMID:14732715</ref><ref>PMID:16027218</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 20179344 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20179344}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:020179344</ref><references group="xtra"/>
+<ref group="xtra">PMID:020179344</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Brodsky, F M.]]