3hkk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3hkk| PDB=3hkk | SCENE= }} | {{STRUCTURE_3hkk| PDB=3hkk | SCENE= }} | ||
===Structure of human Leukotriene C4 synthase in complex with glutathione sulfonate=== | |||
{{ABSTRACT_PUBMED_022217203}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | |||
==About this Structure== | ==About this Structure== | ||
