3crd: Difference between revisions
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{{STRUCTURE_3crd| PDB=3crd | SCENE= }} | {{STRUCTURE_3crd| PDB=3crd | SCENE= }} | ||
===NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES=== | |||
{{ABSTRACT_PUBMED_9695946}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN]] Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34) [MIM:[http://omim.org/entry/614499 614499]]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.<ref>PMID:22279524</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN]] Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:009695946</ref><references group="xtra"/> | <ref group="xtra">PMID:009695946</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chou, J J.]] | [[Category: Chou, J J.]] | ||
