1ug3: Difference between revisions
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{{STRUCTURE_1ug3| PDB=1ug3 | SCENE= }} | {{STRUCTURE_1ug3| PDB=1ug3 | SCENE= }} | ||
===C-terminal portion of human eIF4GI=== | ===C-terminal portion of human eIF4GI=== | ||
==Disease== | |||
[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:[http://omim.org/entry/614251 614251]]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:21907011</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016698542</ref><ref group="xtra">PMID:016156639</ref><ref group="xtra">PMID:016698552</ref><references group="xtra"/> | <ref group="xtra">PMID:016698542</ref><ref group="xtra">PMID:016156639</ref><ref group="xtra">PMID:016698552</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bellsolell, L.]] | [[Category: Bellsolell, L.]] | ||
