2c4g: Difference between revisions
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==Overview== | ==Overview== | ||
We have recently reported about a new class of Aurora-A inhibitors based | We have recently reported about a new class of Aurora-A inhibitors based on a bicyclic tetrahydropyrrolo[3,4-c]pyrazole scaffold. Here we describe the synthesis and early expansion of CDK2/cyclin A-E inhibitors belonging to the same chemical class. Synthesis of the compounds was accomplished using a solution-phase protocol amenable to rapid parallel expansion. Compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit CDK2-mediated tumor cell proliferation have been obtained. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Transferred entry: 2 | [[Category: Transferred entry: 2 7.11 1]] | ||
[[Category: Amici, R.]] | [[Category: Amici, R.]] | ||
[[Category: Bischoff, J | [[Category: Bischoff, J R.]] | ||
[[Category: Brasca, M | [[Category: Brasca, M G.]] | ||
[[Category: Cameron, A.]] | [[Category: Cameron, A.]] | ||
[[Category: Ciomei, M.]] | [[Category: Ciomei, M.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:44:45 2008'' | ||
