1z8d: Difference between revisions
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{{STRUCTURE_1z8d| PDB=1z8d | SCENE= }} | {{STRUCTURE_1z8d| PDB=1z8d | SCENE= }} | ||
===Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[http://omim.org/entry/232600 232600]]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref><ref>PMID:8535454</ref><ref>PMID:7603523</ref><ref>PMID:9506549</ref><ref>PMID:10417800</ref><ref>PMID:10382911</ref><ref>PMID:10382912</ref><ref>PMID:10681080</ref><ref>PMID:10590419</ref><ref>PMID:10714589</ref><ref>PMID:10899452</ref><ref>PMID:11706962</ref><ref>PMID:12031624</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016523484</ref><references group="xtra"/> | <ref group="xtra">PMID:016523484</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphorylase]] | [[Category: Phosphorylase]] | ||
