2wgj: Difference between revisions

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[[Image:2wgj.png|left|200px]]
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{{STRUCTURE_2wgj|  PDB=2wgj  |  SCENE=  }}  
{{STRUCTURE_2wgj|  PDB=2wgj  |  SCENE=  }}  
===X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET===
===X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET===
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{{ABSTRACT_PUBMED_21812414}}
{{ABSTRACT_PUBMED_21812414}}


==About this Structure==
==About this Structure==
[[2wgj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGJ OCA].  
[[2wgj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGJ OCA].  
==See Also==
*[[Hepatocyte growth factor receptor|Hepatocyte growth factor receptor]]


==Reference==
==Reference==
<ref group="xtra">PMID:021812414</ref><references group="xtra"/>
<ref group="xtra">PMID:021812414</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]

Revision as of 11:06, 24 March 2013

Template:STRUCTURE 2wgj

X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET

Template:ABSTRACT PUBMED 21812414

About this Structure

2wgj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Cui JJ, Tran-Dube M, Shen H, Nambu M, Kung PP, Pairish M, Jia L, Meng J, Funk L, Botrous I, McTigue M, Grodsky N, Ryan K, Padrique E, Alton G, Timofeevski S, Yamazaki S, Li Q, Zou H, Christensen J, Mroczkowski B, Bender S, Kania RS, Edwards MP. Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-6363. Epub 2011 Aug 18. PMID:21812414 doi:10.1021/jm2007613

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