2ig0: Difference between revisions
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===Structure of 53BP1/methylated histone peptide complex=== | ===Structure of 53BP1/methylated histone peptide complex=== | ||
{{ABSTRACT_PUBMED_17190600}} | {{ABSTRACT_PUBMED_17190600}} | ||
==Disease== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref><ref>PMID:17190600</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017190600</ref><references group="xtra"/> | <ref group="xtra">PMID:017190600</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mer, G.]] | [[Category: Mer, G.]] | ||
