2c5b: Difference between revisions
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==Overview== | ==Overview== | ||
The fluorinase enzyme from Streptomyces cattleya displays an unusual | The fluorinase enzyme from Streptomyces cattleya displays an unusual ability in biocatalysis in that it forms a C-F bond. We now report that the enzyme will accept 2'-deoxyadenosine in place of adenosine substrates, and structural evidence reveals a reorganisation in hydrogen bonding to accommodate this substrate series. It emerges from this study that the enzyme does not require a planar ribose conformation of the substrate to catalyse C-F bond formation. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya]] | ||
[[Category: Deng, H.]] | [[Category: Deng, H.]] | ||
[[Category: Hagan, D | [[Category: Hagan, D O.]] | ||
[[Category: Mcewan, A | [[Category: Mcewan, A R.]] | ||
[[Category: Mcglinchey, R | [[Category: Mcglinchey, R P.]] | ||
[[Category: Naismith, J | [[Category: Naismith, J H.]] | ||
[[Category: Robinson, D | [[Category: Robinson, D A.]] | ||
[[Category: Spencer, J.]] | [[Category: Spencer, J.]] | ||
[[Category: 5F1]] | [[Category: 5F1]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:01 2008'' | ||
