3f6k: Difference between revisions
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{{STRUCTURE_3f6k| PDB=3f6k | SCENE= }} | {{STRUCTURE_3f6k| PDB=3f6k | SCENE= }} | ||
===Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with neurotensin=== | |||
{{ABSTRACT_PUBMED_19122660}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SORT_HUMAN SORT_HUMAN]] Note=A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SORT_HUMAN SORT_HUMAN]] Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.<ref>PMID:10085125</ref><ref>PMID:11331584</ref><ref>PMID:11390366</ref><ref>PMID:12209882</ref><ref>PMID:14657016</ref><ref>PMID:12598608</ref><ref>PMID:15313463</ref><ref>PMID:14985763</ref><ref>PMID:15930396</ref><ref>PMID:15987945</ref> [[http://www.uniprot.org/uniprot/NEUT_HUMAN NEUT_HUMAN]] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019122660</ref><references group="xtra"/> | <ref group="xtra">PMID:019122660</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Groftehauge, M K.]] | [[Category: Groftehauge, M K.]] | ||
