1v7m: Difference between revisions
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{{STRUCTURE_1v7m| PDB=1v7m | SCENE= }} | {{STRUCTURE_1v7m| PDB=1v7m | SCENE= }} | ||
===Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab=== | |||
{{ABSTRACT_PUBMED_14769915}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN]] Defects in THPO are the cause of thrombocythemia type 1 (THCYT1) [MIM:[http://omim.org/entry/187950 187950]]. A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.<ref>PMID:9425899</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TPO_HUMAN TPO_HUMAN]] Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:014769915</ref><ref group="xtra">PMID:011976502</ref><references group="xtra"/> | <ref group="xtra">PMID:014769915</ref><ref group="xtra">PMID:011976502</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
