3oq9: Difference between revisions

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{{Seed}}
[[Image:3oq9.png|left|200px]]
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{{STRUCTURE_3oq9|  PDB=3oq9  |  SCENE=  }}  
{{STRUCTURE_3oq9|  PDB=3oq9  |  SCENE=  }}  
===Structure of the FAS/FADD death domain assembly===
===Structure of the FAS/FADD death domain assembly===
{{ABSTRACT_PUBMED_20935634}}


==Disease==
[[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production. [[http://www.uniprot.org/uniprot/FADD_HUMAN FADD_HUMAN]] Defects in FADD are the cause of infections recurrent associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:[http://omim.org/entry/613759 613759]]. A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).<ref>PMID:21109225</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20935634}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE]] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). [[http://www.uniprot.org/uniprot/FADD_HUMAN FADD_HUMAN]] Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.<ref>PMID:21109225</ref><ref>PMID:16762833</ref><ref>PMID:19118384</ref><ref>PMID:20935634</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20935634 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20935634}}


==About this Structure==
==About this Structure==
3OQ9 is a 10 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ9 OCA].  
[[3oq9]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ9 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20935634</ref><references group="xtra"/>
<ref group="xtra">PMID:020935634</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Fadd]]
[[Category: Fadd]]
[[Category: Fa]]
[[Category: Fa]]
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