2hp4: Difference between revisions
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{{STRUCTURE_2hp4| PDB=2hp4 | SCENE= }} | {{STRUCTURE_2hp4| PDB=2hp4 | SCENE= }} | ||
===Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor=== | |||
{{ABSTRACT_PUBMED_17243170}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:[http://omim.org/entry/608957 608957]]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD8A_HUMAN CD8A_HUMAN]] Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017243170</ref><references group="xtra"/> | <ref group="xtra">PMID:017243170</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boulter, J M.]] | [[Category: Boulter, J M.]] | ||
