1trn: Difference between revisions
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{{STRUCTURE_1trn| PDB=1trn | SCENE= }} | {{STRUCTURE_1trn| PDB=1trn | SCENE= }} | ||
===CRYSTAL STRUCTURE OF HUMAN TRYPSIN 1: UNEXPECTED PHOSPHORYLATION OF TYROSINE 151=== | |||
{{ABSTRACT_PUBMED_8683601}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[http://omim.org/entry/167800 167800]]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref><ref>PMID:8841182</ref><ref>PMID:11866271</ref><ref>PMID:9322498</ref><ref>PMID:9633818</ref><ref>PMID:10381903</ref><ref>PMID:10204851</ref><ref>PMID:11073545</ref><ref>PMID:11788572</ref><ref>PMID:14695529</ref><ref>PMID:15776435</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:008683601</ref><references group="xtra"/> | <ref group="xtra">PMID:008683601</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Trypsin]] | [[Category: Trypsin]] | ||
