2wwr: Difference between revisions
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{{STRUCTURE_2wwr| PDB=2wwr | SCENE= }} | {{STRUCTURE_2wwr| PDB=2wwr | SCENE= }} | ||
===CRYSTAL STRUCTURE OF HUMAN GLYOXYLATE REDUCTASE HYDROXYPYRUVATE REDUCTASE=== | |||
{{ABSTRACT_PUBMED_16756993}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN]] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:[http://omim.org/entry/260000 260000]]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.<ref>PMID:10484776</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN]] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016756993</ref><references group="xtra"/> | <ref group="xtra">PMID:016756993</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Booth, M P.S.]] | [[Category: Booth, M P.S.]] | ||
