3dlx: Difference between revisions
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{{STRUCTURE_3dlx| PDB=3dlx | SCENE= }} | {{STRUCTURE_3dlx| PDB=3dlx | SCENE= }} | ||
===Crystal structure of human 3-oxoacid CoA transferase 1=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SCOT_HUMAN SCOT_HUMAN]] Defects in OXCT1 are a cause of succinyl-CoA-3-ketoacid-CoA transferase deficiency (SCOTD) [MIM:[http://omim.org/entry/245050 245050]]. A disorder of ketone body metabolism, characterized by episodic ketoacidosis. Patients are usually asymptomatic between episodes.<ref>PMID:10964512</ref><ref>PMID:9671268</ref><ref>PMID:21296660</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SCOT_HUMAN SCOT_HUMAN]] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | |||
==About this Structure== | ==About this Structure== | ||
[[3dlx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLX OCA]. | [[3dlx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLX OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: 3-oxoacid CoA-transferase]] | [[Category: 3-oxoacid CoA-transferase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
