3ik5: Difference between revisions

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[[Image:3ik5.png|left|200px]]
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{{STRUCTURE_3ik5|  PDB=3ik5  |  SCENE=  }}  
{{STRUCTURE_3ik5|  PDB=3ik5  |  SCENE=  }}  
===SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)===
===SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)===
{{ABSTRACT_PUBMED_20124696}}


==Disease==
[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:[http://omim.org/entry/610163 610163]]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.<ref>PMID:16672702</ref>


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==Function==
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[[http://www.uniprot.org/uniprot/CD3Z_HUMAN CD3Z_HUMAN]] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.  
(as it appears on PubMed at http://www.pubmed.gov), where 20124696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20124696}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:020124696</ref><references group="xtra"/>
<ref group="xtra">PMID:020124696</ref><references group="xtra"/><references/>
[[Category: Simian immunodeficiency virus]]
[[Category: Simian immunodeficiency virus]]
[[Category: Kim, W M.]]
[[Category: Kim, W M.]]

Revision as of 16:49, 24 March 2013

Template:STRUCTURE 3ik5

SIVmac239 Nef in complex with TCR zeta ITAM 1 polypeptide (A63-R80)

Template:ABSTRACT PUBMED 20124696

Disease

[CD3Z_HUMAN] Defects in CD247 are the cause of immunodeficiency due to defect in CD3-zeta (CD3ZID) [MIM:610163]. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.[1]

Function

[CD3Z_HUMAN] Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

About this Structure

3ik5 is a 4 chain structure with sequence from Simian immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

  1. Kim WM, Sigalov AB, Stern LJ. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):163-75. Epub 2010 Jan 22. PMID:20124696 doi:10.1107/S090744490904880X
  1. ↑ Rieux-Laucat F, Hivroz C, Lim A, Mateo V, Pellier I, Selz F, Fischer A, Le Deist F. Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency. N Engl J Med. 2006 May 4;354(18):1913-21. PMID:16672702 doi:354/18/1913

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