2cab: Difference between revisions
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[[Image:2cab.gif|left|200px]]<br /> | [[Image:2cab.gif|left|200px]]<br /><applet load="2cab" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2cab" size=" | |||
caption="2cab, resolution 2.0Å" /> | caption="2cab, resolution 2.0Å" /> | ||
'''STRUCTURE, REFINEMENT AND FUNCTION OF CARBONIC ANHYDRASE ISOZYMES. REFINEMENT OF HUMAN CARBONIC ANHYDRASE I'''<br /> | '''STRUCTURE, REFINEMENT AND FUNCTION OF CARBONIC ANHYDRASE ISOZYMES. REFINEMENT OF HUMAN CARBONIC ANHYDRASE I'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of human erythrocyte carbonic anhydrase I has been refined | The structure of human erythrocyte carbonic anhydrase I has been refined to a final R value of 19% to 2-A resolution by a combination of least squares refinement and model fitting in a three-dimensional graphics display. About 300 solvent atoms have been located bound to the protein molecule. An interesting hydrogen bond network involving Zn2+, the liganded solvent, side chain groups of Thr-199, Glu-106, Thr-7, and His-64 through two solvent molecules have been found that may be important for the catalytic mechanism of the carbonic anhydrase. | ||
==About this Structure== | ==About this Structure== | ||
2CAB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. This structure | 2CAB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure supersedes the now removed PDB entry 1CAB. Active as [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAB OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Jones, T | [[Category: Jones, T A.]] | ||
[[Category: Kannan, K | [[Category: Kannan, K K.]] | ||
[[Category: Ramanadham, M.]] | [[Category: Ramanadham, M.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: hydro-lyase]] | [[Category: hydro-lyase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:46:38 2008'' | ||
