2l87: Difference between revisions

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[[Image:2l87.jpg|left|200px]]
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{{STRUCTURE_2l87|  PDB=2l87  |  SCENE=  }}  
{{STRUCTURE_2l87|  PDB=2l87  |  SCENE=  }}  
===The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide===
===The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide===
{{ABSTRACT_PUBMED_21763489}}


==Disease==
[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_21763489}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref><ref>PMID:8663314</ref><ref>PMID:8699119</ref><ref>PMID:8649511</ref><ref>PMID:8649512</ref><ref>PMID:11323418</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 21763489 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21763489}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021763489</ref><references group="xtra"/>
<ref group="xtra">PMID:021763489</ref><references group="xtra"/><references/>
[[Category: Anglister, J.]]
[[Category: Anglister, J.]]
[[Category: Arshava, B.]]
[[Category: Arshava, B.]]
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