3cbb: Difference between revisions
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{{STRUCTURE_3cbb| PDB=3cbb | SCENE= }} | {{STRUCTURE_3cbb| PDB=3cbb | SCENE= }} | ||
===Crystal Structure of Hepatocyte Nuclear Factor 4alpha in complex with DNA: Diabetes Gene Product=== | |||
{{ABSTRACT_PUBMED_18829458}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:[http://omim.org/entry/125850 125850]]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:9313765</ref><ref>PMID:9243109</ref><ref>PMID:9449683</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HNF4A_HUMAN HNF4A_HUMAN]] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018829458</ref><references group="xtra"/> | <ref group="xtra">PMID:018829458</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Adkins, B C.]] | [[Category: Adkins, B C.]] | ||
