2cci: Difference between revisions

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~~[[Image:2cci.png|left|200px]]~~

===CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6===

===~~CRYSTAL STRUCTURE OF PHOSPHO~~-~~CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6===~~

==Disease==

[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>

~~{{ABSTRACT_PUBMED_16707497}}~~

==Function==

[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Non-specific serine/threonine protein kinase]]

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@@ Line 1: / Line 1: @@
-[[Image:2cci.png|left|200px]]
 {{STRUCTURE_2cci|  PDB=2cci  |  SCENE=  }}
+===CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6===
+{{ABSTRACT_PUBMED_16707497}}
-===CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6===
+==Disease==
+[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>
-{{ABSTRACT_PUBMED_16707497}}
+==Function==
+[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
 ==About this Structure==
@@ Line 15: / Line 17: @@
 ==Reference==
-<ref group="xtra">PMID:016707497</ref><ref group="xtra">PMID:016801434</ref><references group="xtra"/>
+<ref group="xtra">PMID:016707497</ref><ref group="xtra">PMID:016801434</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Non-specific serine/threonine protein kinase]]