3n5n: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3n5n| PDB=3n5n | SCENE= }} | {{STRUCTURE_3n5n| PDB=3n5n | SCENE= }} | ||
===Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue=== | |||
{{ABSTRACT_PUBMED_20816984}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN]] Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:[http://omim.org/entry/608456 608456]]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.<ref>PMID:11818965</ref><ref>PMID:12853198</ref><ref>PMID:12606733</ref><ref>PMID:15366000</ref><ref>PMID:18091433</ref><ref>PMID:19953527</ref> Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:[http://omim.org/entry/613659 613659]]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.<ref>PMID:15273732</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MUTYH_HUMAN MUTYH_HUMAN]] Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.<ref>PMID:10684930</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 16: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020816984</ref><references group="xtra"/> | <ref group="xtra">PMID:020816984</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Luncsford, P J.]] | [[Category: Luncsford, P J.]] | ||
