2rrs: Difference between revisions

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~~[[Image:2rrs.jpg|left|200px]]~~

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~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

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===NMR Structure of LC4 transmembrane segment of CCR5===

==Disease==

[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_21647380}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref><ref>PMID:8663314</ref><ref>PMID:8699119</ref><ref>PMID:8649511</ref><ref>PMID:8649512</ref><ref>PMID:11323418</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 21647380 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_21647380}}~~

==About this Structure==

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==Reference==

[[Category: Miyamoto, K.]]

[[Category: Ccr5]]

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@@ Line 1: / Line 1: @@
-[[Image:2rrs.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2rrs", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2rrs|  PDB=2rrs  |  SCENE=  }}
 ===NMR Structure of LC4 transmembrane segment of CCR5===
+{{ABSTRACT_PUBMED_21647380}}
+==Disease==
+[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Genetic variation in CCR5 is associated with susceptibility to diabetes mellitus insulin-dependent type 22 (IDDM22) [MIM:[http://omim.org/entry/612522 612522]]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.<ref>PMID:19073967</ref>
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_21647380}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/CCR5_HUMAN CCR5_HUMAN]] Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.<ref>PMID:8639485</ref><ref>PMID:8663314</ref><ref>PMID:8699119</ref><ref>PMID:8649511</ref><ref>PMID:8649512</ref><ref>PMID:11323418</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 21647380 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21647380}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:021647380</ref><references group="xtra"/>
+<ref group="xtra">PMID:021647380</ref><references group="xtra"/><references/>
 [[Category: Miyamoto, K.]]
 [[Category: Ccr5]]