3pcv: Difference between revisions
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{{STRUCTURE_3pcv| PDB=3pcv | SCENE= }} | {{STRUCTURE_3pcv| PDB=3pcv | SCENE= }} | ||
===Crystal structure analysis of human leukotriene C4 synthase at 1.9 angstrom resolution=== | |||
{{ABSTRACT_PUBMED_21454538}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021454538</ref><ref group="xtra">PMID:017632548</ref><references group="xtra"/> | <ref group="xtra">PMID:021454538</ref><ref group="xtra">PMID:017632548</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ago, H.]] | [[Category: Ago, H.]] | ||
