3fmo: Difference between revisions

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[[Image:3fmo.png|left|200px]]
{{STRUCTURE_3fmo|  PDB=3fmo  |  SCENE=  }}  
{{STRUCTURE_3fmo|  PDB=3fmo  |  SCENE=  }}  
===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===
{{ABSTRACT_PUBMED_19208808}}


===Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19===
==Disease==
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.  Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.


{{ABSTRACT_PUBMED_19208808}}
==Function==
[[http://www.uniprot.org/uniprot/NU214_HUMAN NU214_HUMAN]] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:019208808</ref><references group="xtra"/>
<ref group="xtra">PMID:019208808</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blobel, G.]]
[[Category: Blobel, G.]]

Revision as of 20:30, 24 March 2013

Template:STRUCTURE 3fmo

Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19

Template:ABSTRACT PUBMED 19208808

Disease

[NU214_HUMAN] Note=A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene. Note=A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.

Function

[NU214_HUMAN] May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. [DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

About this Structure

3fmo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Napetschnig J, Kassube SA, Debler EW, Wong RW, Blobel G, Hoelz A. Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3089-94. Epub 2009 Feb 10. PMID:19208808

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