3ich: Difference between revisions
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{{STRUCTURE_3ich| PDB=3ich | SCENE= }} | {{STRUCTURE_3ich| PDB=3ich | SCENE= }} | ||
===Crystal structure of cyclophilin B at 1.2 A resolution=== | |||
{{ABSTRACT_PUBMED_20801878}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PPIB_HUMAN PPIB_HUMAN]] Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:[http://omim.org/entry/259440 259440]]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.<ref>PMID:19781681</ref><ref>PMID:20089953</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PPIB_HUMAN PPIB_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020801878</ref><references group="xtra"/> | <ref group="xtra">PMID:020801878</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Peptidylprolyl isomerase]] | [[Category: Peptidylprolyl isomerase]] | ||
