3kv2: Difference between revisions

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{{Seed}}
[[Image:3kv2.png|left|200px]]
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{{STRUCTURE_3kv2|  PDB=3kv2  |  SCENE=  }}  
{{STRUCTURE_3kv2|  PDB=3kv2  |  SCENE=  }}  
===HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR N(omega)-hydroxy-nor-L-arginine (nor-NOHA)===
===HIGH RESOLUTION STRUCTURE OF HUMAN ARGINASE I IN COMPLEX WITH THE STRONG INHIBITOR N(omega)-hydroxy-nor-L-arginine (nor-NOHA)===
{{ABSTRACT_PUBMED_20153713}}


 
==Disease==
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[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref><ref>PMID:7649538</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_20153713}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20153713 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20153713}}


==About this Structure==
==About this Structure==
3KV2 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KV2 OCA].  
[[3kv2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KV2 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20153713</ref><references group="xtra"/>
<ref group="xtra">PMID:020153713</ref><references group="xtra"/><references/>
[[Category: Arginase]]
[[Category: Arginase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Costanzo, L Di.]]
[[Category: Costanzo, L Di.]]
[[Category: Alternative splicing]]
[[Category: Arginase]]
[[Category: Arginase]]
[[Category: Arginine metabolism]]
[[Category: Arginine metabolism]]
[[Category: Cytoplasm]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
[[Category: High resolution]]
[[Category: High resolution]]
Line 39: Line 24:
[[Category: Nor-noha]]
[[Category: Nor-noha]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Strong inhibitor]]
[[Category: Strong inhibitor]]
[[Category: Urea cycle]]
[[Category: Urea cycle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:23:28 2010''