1imv: Difference between revisions
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{{STRUCTURE_1imv| PDB=1imv | SCENE= }} | {{STRUCTURE_1imv| PDB=1imv | SCENE= }} | ||
===2.85 A crystal structure of PEDF=== | |||
{{ABSTRACT_PUBMED_11562499}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PEDF_HUMAN PEDF_HUMAN]] Defects in SERPINF1 are the cause of osteogenesis imperfecta type 12 (OI12) [MIM:[http://omim.org/entry/613982 613982]]. OI12 is a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. OI12 is characterized by features compatible with osteogenesis imperfecta type III in the Sillence classification. Patients have normal grayish sclerae and fractures of long bones and severe vertebral compression fractures, with resulting deformities observed as early as the first year of life.<ref>PMID:21353196</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PEDF_HUMAN PEDF_HUMAN]] Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.<ref>PMID:8226833</ref><ref>PMID:7592790</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011562499</ref><references group="xtra"/> | <ref group="xtra">PMID:011562499</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gettins, P G.W.]] | [[Category: Gettins, P G.W.]] | ||
