3ul7: Difference between revisions

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~~[[Image:3ul7.jpg|left|200px]]~~

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===Crystal structure of the TV3 mutant F63W===

==Disease==

[[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:[http://omim.org/entry/611488 611488]]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_22363519}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.<ref>PMID:20711192</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 22363519 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_22363519}}~~

==About this Structure==

[[3ul7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens,_eptatretus_burgeri Homo sapiens, eptatretus~~ burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL7 OCA].

[[3ul7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL7 OCA].

==Reference==

[[Category: ~~Homo sapiens, eptatretus~~ burgeri]]

[[Category: Eptatretus burgeri]]

[[Category: Cheong, H K.]]

[[Category: Jeon, Y H.]]

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@@ Line 1: / Line 1: @@
-[[Image:3ul7.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3ul7", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3ul7|  PDB=3ul7  |  SCENE=  }}
 ===Crystal structure of the TV3 mutant F63W===
+{{ABSTRACT_PUBMED_22363519}}
+==Disease==
+[[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:[http://omim.org/entry/611488 611488]]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22363519}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/TLR4_HUMAN TLR4_HUMAN]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.<ref>PMID:20711192</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22363519 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_22363519}}
 ==About this Structure==
-[[3ul7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_eptatretus_burgeri Homo sapiens, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL7 OCA].
+[[3ul7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UL7 OCA].
 ==Reference==
-<ref group="xtra">PMID:022363519</ref><references group="xtra"/>
+<ref group="xtra">PMID:022363519</ref><references group="xtra"/><references/>
-[[Category: Homo sapiens, eptatretus burgeri]]
+[[Category: Eptatretus burgeri]]
 [[Category: Cheong, H K.]]
 [[Category: Jeon, Y H.]]