3bn9: Difference between revisions
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{{STRUCTURE_3bn9| PDB=3bn9 | SCENE= }} | {{STRUCTURE_3bn9| PDB=3bn9 | SCENE= }} | ||
===Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2=== | |||
{{ABSTRACT_PUBMED_18514224}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018514224</ref><references group="xtra"/> | <ref group="xtra">PMID:018514224</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Matriptase]] | [[Category: Matriptase]] | ||
