3kt9: Difference between revisions

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~~[[Image:3kt9.png|left|200px]]~~

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===Aprataxin FHA Domain===

==Disease==

[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome (AOA) [MIM:[http://omim.org/entry/208920 208920]]. AOA is an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy.<ref>PMID:11586299</ref><ref>PMID:11586300</ref><ref>PMID:12196655</ref><ref>PMID:12629250</ref><ref>PMID:14506070</ref><ref>PMID:15852392</ref><ref>PMID:15699391</ref>

~~<!--~~

==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_20008512}}, adds the Publication Abstract to the page~~

[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.<ref>PMID:14755728</ref><ref>PMID:15044383</ref><ref>PMID:16547001</ref><ref>PMID:16964241</ref><ref>PMID:17276982</ref>

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20008512 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_20008512}}~~

==About this Structure==

~~3KT9~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA].

[[3kt9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Cherry, A L.]]

[[Category: Smerdon, S J.]]

~~[[Category: Alternative splicing]]~~

[[Category: Amp hydrolase]]

[[Category: Beta sandwich]]

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Line 29:

[[Category: Neurodegeneration]]

[[Category: Nucleus]]

~~[[Category: Zinc]]~~

[[Category: Zinc-finger]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:24:50 2010''~~

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@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3kt9.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3kt9", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3kt9|  PDB=3kt9  |  SCENE=  }}
 ===Aprataxin FHA Domain===
+{{ABSTRACT_PUBMED_20008512}}
+==Disease==
+[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome (AOA) [MIM:[http://omim.org/entry/208920 208920]]. AOA is an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy.<ref>PMID:11586299</ref><ref>PMID:11586300</ref><ref>PMID:12196655</ref><ref>PMID:12629250</ref><ref>PMID:14506070</ref><ref>PMID:15852392</ref><ref>PMID:15699391</ref>
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_20008512}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.<ref>PMID:14755728</ref><ref>PMID:15044383</ref><ref>PMID:16547001</ref><ref>PMID:16964241</ref><ref>PMID:17276982</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 20008512 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20008512}}
 ==About this Structure==
-KT9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA].
+[[3kt9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA].
 ==Reference==
-<ref group="xtra">PMID:20008512</ref><references group="xtra"/>
+<ref group="xtra">PMID:020008512</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cherry, A L.]]
 [[Category: Smerdon, S J.]]
-[[Category: Alternative splicing]]
 [[Category: Amp hydrolase]]
 [[Category: Beta sandwich]]
@@ Line 40: / Line 29: @@
 [[Category: Neurodegeneration]]
 [[Category: Nucleus]]
-[[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:24:50 2010''