1k1a: Difference between revisions
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{{STRUCTURE_1k1a| PDB=1k1a | SCENE= }} | {{STRUCTURE_1k1a| PDB=1k1a | SCENE= }} | ||
===Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family=== | |||
{{ABSTRACT_PUBMED_11707390}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BCL3_HUMAN BCL3_HUMAN]] Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BCL3_HUMAN BCL3_HUMAN]] Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).<ref>PMID:8453667</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011707390</ref><references group="xtra"/> | <ref group="xtra">PMID:011707390</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cramer, P.]] | [[Category: Cramer, P.]] | ||
Revision as of 22:05, 24 March 2013
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family
Template:ABSTRACT PUBMED 11707390
Disease
[BCL3_HUMAN] Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.
Function
[BCL3_HUMAN] Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).[1]
About this Structure
1k1a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Muller CW. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J. 2001 Nov 15;20(22):6180-90. PMID:11707390 doi:10.1093/emboj/20.22.6180
