2kef: Difference between revisions
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{{STRUCTURE_2kef| PDB=2kef | SCENE= }} | {{STRUCTURE_2kef| PDB=2kef | SCENE= }} | ||
===Solution NMR structures of human hepcidin at 325K=== | |||
{{ABSTRACT_PUBMED_19553669}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[http://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref><ref>PMID:12915468</ref><ref>PMID:14630809</ref><ref>PMID:14670915</ref><ref>PMID:15099344</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019553669</ref><references group="xtra"/> | <ref group="xtra">PMID:019553669</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arvedson, T.]] | [[Category: Arvedson, T.]] | ||
