2qic: Difference between revisions
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{{STRUCTURE_2qic| PDB=2qic | SCENE= }} | {{STRUCTURE_2qic| PDB=2qic | SCENE= }} | ||
===Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide=== | |||
{{ABSTRACT_PUBMED_18533182}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:10866301</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ING1_HUMAN ING1_HUMAN]] Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.<ref>PMID:9440695</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018533182</ref><references group="xtra"/> | <ref group="xtra">PMID:018533182</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Champagne, K.]] | [[Category: Champagne, K.]] | ||
