3qn7: Difference between revisions

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[[Image:3qn7.jpg|left|200px]]
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{{STRUCTURE_3qn7|  PDB=3qn7  |  SCENE=  }}  
{{STRUCTURE_3qn7|  PDB=3qn7  |  SCENE=  }}  
===Potent and selective bicyclic peptide inhibitor (UK18) of human urokinase-type plasminogen activator(uPA)===
===Potent and selective bicyclic peptide inhibitor (UK18) of human urokinase-type plasminogen activator(uPA)===
{{ABSTRACT_PUBMED_17692534}}


==Disease==
[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>


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==Function==
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[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.  
(as it appears on PubMed at http://www.pubmed.gov), where 17692534 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17692534}}


==About this Structure==
==About this Structure==
[[3qn7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QN7 OCA].  
[[3qn7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QN7 OCA].  
==See Also==
*[[Urokinase|Urokinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:017692534</ref><ref group="xtra">PMID:008591045</ref><references group="xtra"/>
<ref group="xtra">PMID:017692534</ref><ref group="xtra">PMID:008591045</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: U-plasminogen activator]]
[[Category: U-plasminogen activator]]
Retrieved from "https://proteopedia.org/3qn7"