3p7f: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3p7f.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3p7f", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3p7f|  PDB=3p7f  |  SCENE=  }}  
{{STRUCTURE_3p7f|  PDB=3p7f  |  SCENE=  }}  
===Structure of the human Langerin carbohydrate recognition domain===
===Structure of the human Langerin carbohydrate recognition domain===
{{ABSTRACT_PUBMED_18061677}}


==Disease==
[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>


<!--
==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_18061677}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 18061677 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18061677}}


==About this Structure==
==About this Structure==
3P7F is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bbs 3bbs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7F OCA].  
[[3p7f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bbs 3bbs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7F OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:18061677</ref><references group="xtra"/>
<ref group="xtra">PMID:018061677</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Schiefner, A.]]
[[Category: Schiefner, A.]]
Line 38: Line 28:
[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Sugar binding]]
[[Category: Sugar binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:15:26 2010''
Retrieved from "https://proteopedia.org/3p7f"