3c22: Difference between revisions

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~~[[Image:3c22.png|left|200px]]~~

===Crystal structure of the carbohydrate recognition domain of human Langerin===

===~~Crystal structure~~ of the ~~carbohydrate recognition domain~~ of ~~human Langerin===~~

==Disease==

[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>

~~{{ABSTRACT_PUBMED_19175323}}~~

==Function==

[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Thepaut, M.]]

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-[[Image:3c22.png|left|200px]]
 {{STRUCTURE_3c22|  PDB=3c22  |  SCENE=  }}
+===Crystal structure of the carbohydrate recognition domain of human Langerin===
+{{ABSTRACT_PUBMED_19175323}}
-===Crystal structure of the carbohydrate recognition domain of human Langerin===
+==Disease==
+[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[http://omim.org/entry/613393 613393]]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref><ref>PMID:16567809</ref>
-{{ABSTRACT_PUBMED_19175323}}
+==Function==
+[[http://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN]] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref><ref>PMID:17334373</ref><ref>PMID:20026605</ref><ref>PMID:20097424</ref>
 ==About this Structure==
@@ Line 11: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:019175323</ref><ref group="xtra">PMID:018259063</ref><references group="xtra"/>
+<ref group="xtra">PMID:019175323</ref><ref group="xtra">PMID:018259063</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Thepaut, M.]]