4axb: Difference between revisions

Line 1:

~~[[Image:4axb.png|left|200px]]~~

===Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM===

===~~Crystal structure~~ of ~~soman-aged human~~ butyrylcholinesterase ~~in complex with 2-PAM===~~

==Disease==

[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

~~{{ABSTRACT_PUBMED_22922115}}~~

==Function==

[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>

==About this Structure==

[[4axb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXB OCA].

==See Also==

*[[Butyrylcholinesterase|Butyrylcholinesterase]]

==Reference==

[[Category: Cholinesterase]]

[[Category: Homo sapiens]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:4axb.png|left|200px]]
 {{STRUCTURE_4axb|  PDB=4axb  |  SCENE=  }}
+===Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM===
+{{ABSTRACT_PUBMED_22922115}}
-===Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM===
+==Disease==
+[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
-{{ABSTRACT_PUBMED_22922115}}
+==Function==
+[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>
 ==About this Structure==
 [[4axb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXB OCA].
+==See Also==
+*[[Butyrylcholinesterase|Butyrylcholinesterase]]
+==Reference==
+<references group="xtra"/><references/>
 [[Category: Cholinesterase]]
 [[Category: Homo sapiens]]