2obv: Difference between revisions
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{{STRUCTURE_2obv| PDB=2obv | SCENE= }} | {{STRUCTURE_2obv| PDB=2obv | SCENE= }} | ||
===Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN]] Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:[http://omim.org/entry/250850 250850]]; also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity.<ref>PMID:7560086</ref><ref>PMID:8770875</ref><ref>PMID:9042912</ref><ref>PMID:10677294</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/METK1_HUMAN METK1_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[S-adenosylmethionine synthetase|S-adenosylmethionine synthetase]] | *[[S-adenosylmethionine synthetase|S-adenosylmethionine synthetase]] | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Methionine adenosyltransferase]] | [[Category: Methionine adenosyltransferase]] | ||
