2h9g: Difference between revisions
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{{STRUCTURE_2h9g| PDB=2h9g | SCENE= }} | {{STRUCTURE_2h9g| PDB=2h9g | SCENE= }} | ||
===Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)=== | |||
{{ABSTRACT_PUBMED_16859704}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 16: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016859704</ref><references group="xtra"/> | <ref group="xtra">PMID:016859704</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Compaan, D M.]] | [[Category: Compaan, D M.]] | ||
