2os6: Difference between revisions
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{{STRUCTURE_2os6| PDB=2os6 | SCENE= }} | {{STRUCTURE_2os6| PDB=2os6 | SCENE= }} | ||
===Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1=== | |||
{{ABSTRACT_PUBMED_018411422}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN]] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref> [[http://www.uniprot.org/uniprot/PLXB1_HUMAN PLXB1_HUMAN]] Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:12198496</ref><ref>PMID:12196628</ref><ref>PMID:15210733</ref><ref>PMID:19843518</ref><ref>PMID:20877282</ref><ref>PMID:21912513</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2os6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS6 OCA]. | [[2os6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS6 OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Huang, H.]] | [[Category: Huang, H.]] | ||
