3lgl: Difference between revisions
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{{STRUCTURE_3lgl| PDB=3lgl | SCENE= }} | {{STRUCTURE_3lgl| PDB=3lgl | SCENE= }} | ||
===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2=== | ===Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2=== | ||
{{ABSTRACT_PUBMED_20307547}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref><ref>PMID:17190600</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3lgl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGL OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020307547</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kutateladze, T G.]] | [[Category: Kutateladze, T G.]] | ||
| Line 36: | Line 26: | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 00:29, 25 March 2013
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2
Template:ABSTRACT PUBMED 20307547
Disease
[TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
Function
[TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.[1][2]
About this Structure
3lgl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG. Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 2010 May 14;398(4):489-96. Epub 2010 Mar 20. PMID:20307547 doi:10.1016/j.jmb.2010.03.024
- ↑ Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science. 2002 Nov 15;298(5597):1435-8. Epub 2002 Oct 3. PMID:12364621 doi:10.1126/science.1076182
- ↑ Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29;127(7):1361-73. PMID:17190600 doi:10.1016/j.cell.2006.10.043
